Authors :
Prof. Issa Alsalloum , Fadi Abdulmassih , and Kristina alsalloum
Name :
FORMULATION AND EVALUATION OF METOPROLOLOL SUCCINATE SUSTAINED RELEASE MATRIX TABLETS USING HPMC 100000 AND STEARIC ACID
Published in :
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
Abstract :
The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol Succinate 50 mg, 100 mg, and 200 mg using hydrophilic polymers such as HPMC 100000 and hydrophobic excipient such as stearic acid. five batches were prepared by using Metoprolol Succinate 50 mg and HPMC 100000 in drug: polymer ratio of 1:0.5, 1:1, 1:1.5, 1:2, 1:2.5, and five batches were prepared by using Metoprolol Succinate 100 mg, HPMC 100000 and stearic acid in ratios : 1:2.5:0, 1:2.5:0.25, 1:2.5:0.5, 1:2.5:0.75, 1:2.5:1.and five batches were prepared by using Metoprolol Succinate 200 mg, HPMC 100000 and stearic acid in ratios : 1:2.5:0, 1:2.5:1,
1:2.5:1.25 1:2.75:1, 1:3:1. Matrix tablets were prepared by wet granulation method and evaluated for weight variation, content uniformity, friability, hardness, thickness and in vitro dissolution. Among the formulations studied, formulation F5 containing Metoprolol Succinate 50 mg and HPMC 100000 in drug: polymer ratio of (1:2.5) showed sustained release of drug for 10 h with cumulative percent release of 55% , formulation F6/4 Metoprolol Succinate 100 mg, HPMC 1000000 and stearic acid in ratio: (1:2.5:1) showed sustained release of drug for 10 h with cumulative percent release of 47,8%, formulation F7/4: Metoprolol Succinate 200 mg, HPMC 1000000 and stearic acid in ratios: (1:3:1) showed sustained release of drug for 10 h with cumulative percent release of 48,2%. Formulations with standard specifications were subjected to stability studies according to ICH Q1A guidelines. It was found that most of the formulations prepared conform to compendial specifications and there was no significant change in active content and dissolution profile in the accelerated stability studies.
Authors :
Anas Taweelh, Al Hawash Private University
Name :
Study of Toxic Effects of Adriamycin Drug on Female Sex Cells and Comparing
Honey and Ginseng Ability to Treat These Effects
Published in :
International Journal of
Pharmaceutical Care & Health
Abstract :
Objective: This study aims to investigate the ability of a certain mixture of honey with royal jelly and ginseng root herb to prevent the toxic side effects, caused by the adriamycin drug. One of the most important side effects of this drug is the changein the structure of cell and tissue of the ovary, especially Graafian follicles, which may lead to sexual ovarian hormonal disorders. consequently, this will lead to menstrual disorders that lead in certain cases to early menopause (infertility), and decreasein the reproductive capacity.
Methods: First Study: field study, included 500 women who were treated with adriamycin. second study: An experimental study was conducted on 75 young adult female Syrian hamsters, twenty-five hamsters were injected with Adriamycin drug and another 25 females were injected with Adriamycin drug after oral administration with preventive dose of honey and royal jelly and another 25 females were injected with Adriamycin drug after oral administration with preventive dose of ginseng. histologically study of the ovaries and sex hormones.
Results: ginseng root herb is not considered a sufficient preventive supplement, as it did not protect the tissue structures. However, it contributes to raising the levels of sex hormones. but the honey with royal jelly has a clear role in renovating and They protect the tissue structure of the ovary, enhancing the hormonal balance, and prevents the hormonal disorders, and the occurrence of early menopause caused by adriamycin.
Conclusion: The Honey with royal jelly contributes, as a preventive dose, in preventing the side effects of adriamycin drug, and reducing the reproductive aging and early menopause.
Keywords:
Adriamycin; Ginseng root herb; Graafian follicles; Honey; Menopause; Panax ginseng; Royal jelly; Sex hormones;
Syrian hamster.
Author :
Alshaarani F,Department of Fixed Prosthodontics, Faculty of Dentistry, Alhwash University, Homs, SyriaOPINION
Name :
Is It Time to Reconsider Some Terminology Change in Dentistry?
Published in :
Journal of Oral Health and Dental Science
References :
1. Donaldson KJ (2012) Fundamentals of fixed prosthodontics, fourth edition. Br Dent J 213: 427.
3. Davies SJ (2007) Malocclusion – a term in need of dropping or redefinition? Br Dent J 202: 519-20.
2. Gallico M (1988) Concise illustrated dental dictionary. J Dent 16: 165.