P_Research Archives - Al-Hawash Private University

EFFICACY OF A 12-MONTH VERY LOW-CALORIE KETOGENIC DIET (VLCKD) IN GLYCEMIA COMPARED WITH PARAMETERS BEFORE STARTING THE REGIME IN PATIENTS WITH OBESITY AND TYPE 2 DIABETES. A CLINICAL STUDY

univ-admin — Thu, 01 Aug 2024 10:25:14 +0000

Authors :

Prof. Hala Hassan Deeb

Research Scholar:

Department of Clinical Biochemistry, Faculty of Pharmacy, Al Hawash Private University, Syria- Homs.

Published in :

International Journal of Pharmaceutical Sciences and Research

www.ijpsr.com

ABSTRACT :

In obese patients with noninsulin-dependent diabetes mellitus (NIDDM), reducing calorie intake improves glycemic control. The present study tested the theory that controlling calorie intake has an important role in long term, independent of weight loss in metabolic regulation of NIDDM patients. 23 women included in this study were selected, Antidiabetic therapy (except metformin) was discontinued concurrently with the start of VLCKD diet and Parameters were collected at starting program and once every 3 months for a year. In result, on T3 (after 9 months) ofVLCKD restriction produced substantial decreases in fasting plasma glucose for (19±9.31 ), HbA1c % (1±0.34),Weight loss (35.6±9.9), BMI (11.9±2.5 ), Tri Acyl Glycerol(22.99±19.27) and Total Cholesterol (52.5±4.89), and no significant decreasing in Creatinine is found .While on T4 ( after 12 months)there is a significant decreasing in: fasting plasma glucose for (18±8.41 ), HbA1c % (1±0.5), Weight loss (33.5±10.3), BMI (12.3±2.2 ), Tri Acyl Glycerol (18±22.1) and Total Cholesterol (46.7±21.5), and no significant decreasing in Creatinine. It is important to noticethe stability of biochemical parameters after nine months of study. These findings indicate that VLCKD restriction has an important regulatory and safe effect on the metabolism of obese patients with NIDDM that is independent of weight loss.

Keywords :

VLCKD, Obesity, Diabetes, Body Mass index, Fasting plasma glucose, Lipid profile, Weight-loss.

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The post EFFICACY OF A 12-MONTH VERY LOW-CALORIE KETOGENIC DIET (VLCKD) IN GLYCEMIA COMPARED WITH PARAMETERS BEFORE STARTING THE REGIME IN PATIENTS WITH OBESITY AND TYPE 2 DIABETES. A CLINICAL STUDY appeared first on Al-Hawash Private University.

A STATISTICAL STUDY OF THE PREVALENCE OF CELIAC DISEASE IN ADULTS IN TWO SYRIAN GOVERNORATES (HOMS- TARTOUS) DURING THE PERIOD OF 2014-2022

Max — Mon, 01 Jul 2024 18:40:51 +0000

Authors :

Prof. Hala Hassan Deeb

Name :

A STATISTICAL STUDY OF THE PREVALENCE OF CELIAC DISEASE IN ADULTS IN TWO SYRIAN GOVERNORATES (HOMS- TARTOUS) DURING THE PERIOD OF 2014-2022

Published in :

International Journal of Pharmaceutical Sciences and Research

Abstract :

Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. Our study was limited to a survey of the prevalence of Celiac disease in adult in two Syrian governorates (Homs and Tartous), Statistics were collected from hospitals and clinics of gastroenterologists and nutritionists, during the period of 2014-2022. 4000 cases of Celiac disease were recorded in these two Syrian governorates with a population of about 5 million people with ages ranging from 20-33, that is 0.08% in these cases. The presence of HLA class II antigens was observed in all people with Celiac disease as HLA DQ2 was found in 82% of celiac disease patients, and HLA DQ8 was found in the rest. It is very important that follow-up showed that the results of antibody tests (Transglutaminase IgA) in patients adhering to the gluten-free diet decreased from 200 to 100 “during a year of treatment” and to 20 “during two years of treatment” in all patients. The decrease in antibodies was accompanied by a clear improvement in the absorption of iron and other elements, and a good improvement in the growth of intestinal villi in patients who underwent intestinal biopsies. In the absence of Celiac disease many people identifying themselves as “being gluten sensitive”. The biological basis of gluten induced symptoms in the absence of Celiac disease is largely unknown but may be related to immune responses to components of wheat apart from gluten.

Keywords :

Autoimmune, Celiac disease, Gluten-free diet, Nonceliac gluten sensitivity, Tissue transglutaminase

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The post A STATISTICAL STUDY OF THE PREVALENCE OF CELIAC DISEASE IN ADULTS IN TWO SYRIAN GOVERNORATES (HOMS- TARTOUS) DURING THE PERIOD OF 2014-2022 appeared first on Al-Hawash Private University.

Vitamin D Levels as a Neurosteroid Hormone Associated with the Developing of Catecholamines in Healthy Adults: A Clinical Study in a Group of Healthy Adult Women

Max — Mon, 03 Jun 2024 18:52:02 +0000

Authors :

Prof. Hala Hassan Deeb

Name :

Vitamin D Levels as a Neurosteroid Hormone Associated with the Developing of
Catecholamines in Healthy Adults: A Clinical Study in a Group of Healthy Adult Women

Published in :

International Journal of Innovative Science and Research Technology

https://doi.org/10.38124/ijisrt/IJISRT24JUN1396

Abstract :

Vit D deficiency is a public health problem worldwide. According to epidemiological studies, low Vit D levels have been associated with an increased risk of certain neurodevelopmental disorders, including autism spectrum disorder, but the risk of high concentration of Vit D is not clearly affect in nervous system.. In this research, we studied whether vitamin D concentrations were associated with the activity of the nervous system in healthy people by comparing catecholamines concentrations in blood of 42 healthy women (age = 40-50 years old, body mass index: 22.7 ± 2.1 kg/m2). We had three groups as Vit D levels: (Deficient: vit D: ≤ 20 ng/L), (insufficient vita D 20-29 ng/L), (Sufficient vit D: ≥30≤70 ng/L). In our study:_ Plasma Noradrenaline decreased statistically significant ( p˂0.005) in high levels of vit D, _ Plasma Adrenaline increased statistically significant ( p˂0.005) in high levels of vit D,_ Plasma Dopamine increased statistically significant only in high levels of vitamin D. It should be mentioned that high levels of vita D has also been related to mood disorders, movement and a Calcium status. There was a statistical association between several measures of nervous system, hormones activity and vita D levels. This suggests that vita D induces catecholamine synthesis and/or secretion.

Keywords :

Adrenaline, Dopamine, Catecholamines, MAO, Vitamin D.

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The post Vitamin D Levels as a Neurosteroid Hormone Associated with the Developing of Catecholamines in Healthy Adults: A Clinical Study in a Group of Healthy Adult Women appeared first on Al-Hawash Private University.

Resistance to Antibiotics used in Treating Gum infections: A Cross-Sectional Study based on Gum Disease Patients in Syria in the Period of Covid 19

Max — Sat, 01 Jun 2024 21:30:43 +0000

Authors :

Prof. Hala Hassan Deeb

Name :

Resistance to Antibiotics used in Treating Gum infections: A Cross-Sectional Study based on Gum Disease Patients in Syria in the Period of Covid 19

Published in :

International Journal of Innovative Science and Research Technology

https://doi.org/10.38124/ijisrt/IJISRT24JUN245

ABSTRACT :

Since the mouth is the ideal habitat for the development of all types of organisms, the gums are likely to be exposed to many diseases caused by certain types of bacteria. Therefore, it is necessary to constantly search for suitable types of effective antibiotics that can eliminate gum infections.
A paper research includes a set of questions. The paper research questionnaire was distributed to one hundred dentists with an average experience of no less than 9 years. The research form addressed eight antibiotics recommended for use in treating Gum infections. In a statistical analysis of doctors’ answers about the most common antibiotics they use to treat gum infections, metronidazole ranked first, followed by amoxicillin and valdoxycycline. While clindamycin and ciprofloxacin ranked last. Doctors must currently commit not to prescribe antibiotics when there is a possibility of a patient’s spontaneous recovery, for fear of incorrect use of antibiotics, which leads to an increase in the spread of bacterial resistance.

Keywords :

Gum Infections – Antibiotics – Bacterial Resistance

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The post Resistance to Antibiotics used in Treating Gum infections: A Cross-Sectional Study based on Gum Disease Patients in Syria in the Period of Covid 19 appeared first on Al-Hawash Private University.

FORMULATION AND EVALUATION OF METOPROLOLOL SUCCINATE SUSTAINED RELEASE MATRIX TABLETS USING HPMC 100000 AND STEARIC ACID

univ-admin — Mon, 31 Aug 2020 21:38:39 +0000

Authors :

Prof. Issa Alsalloum , Fadi Abdulmassih , and Kristina alsalloum

Name :

FORMULATION AND EVALUATION OF METOPROLOLOL SUCCINATE SUSTAINED RELEASE MATRIX TABLETS USING HPMC 100000 AND STEARIC ACID

Published in :

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Abstract :

The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol Succinate 50 mg, 100 mg, and 200 mg using hydrophilic polymers such as HPMC 100000 and hydrophobic excipient such as stearic acid. five batches were prepared by using Metoprolol Succinate 50 mg and HPMC 100000 in drug: polymer ratio of 1:0.5, 1:1, 1:1.5, 1:2, 1:2.5, and five batches were prepared by using Metoprolol Succinate 100 mg, HPMC 100000 and stearic acid in ratios : 1:2.5:0, 1:2.5:0.25, 1:2.5:0.5, 1:2.5:0.75, 1:2.5:1.and five batches were prepared by using Metoprolol Succinate 200 mg, HPMC 100000 and stearic acid in ratios : 1:2.5:0, 1:2.5:1,
1:2.5:1.25 1:2.75:1, 1:3:1. Matrix tablets were prepared by wet granulation method and evaluated for weight variation, content uniformity, friability, hardness, thickness and in vitro dissolution. Among the formulations studied, formulation F5 containing Metoprolol Succinate 50 mg and HPMC 100000 in drug: polymer ratio of (1:2.5) showed sustained release of drug for 10 h with cumulative percent release of 55% , formulation F6/4 Metoprolol Succinate 100 mg, HPMC 1000000 and stearic acid in ratio: (1:2.5:1) showed sustained release of drug for 10 h with cumulative percent release of 47,8%, formulation F7/4: Metoprolol Succinate 200 mg, HPMC 1000000 and stearic acid in ratios: (1:3:1) showed sustained release of drug for 10 h with cumulative percent release of 48,2%. Formulations with standard specifications were subjected to stability studies according to ICH Q1A guidelines. It was found that most of the formulations prepared conform to compendial specifications and there was no significant change in active content and dissolution profile in the accelerated stability studies.

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Study of Toxic Effects of Adriamycin Drug on Female Sex Cells and Comparing Honey and Ginseng Ability to Treat These Effects

univ-admin — Fri, 26 Apr 2019 22:26:47 +0000

Authors :

Anas Taweelh, Al Hawash Private University

Name :

Study of Toxic Effects of Adriamycin Drug on Female Sex Cells and Comparing
Honey and Ginseng Ability to Treat These Effects

Published in :

International Journal of
Pharmaceutical Care & Health

Abstract :

Objective: This study aims to investigate the ability of a certain mixture of honey with royal jelly and ginseng root herb to prevent the toxic side effects, caused by the adriamycin drug. One of the most important side effects of this drug is the changein the structure of cell and tissue of the ovary, especially Graafian follicles, which may lead to sexual ovarian hormonal disorders. consequently, this will lead to menstrual disorders that lead in certain cases to early menopause (infertility), and decreasein the reproductive capacity.
Methods: First Study: field study, included 500 women who were treated with adriamycin. second study: An experimental study was conducted on 75 young adult female Syrian hamsters, twenty-five hamsters were injected with Adriamycin drug and another 25 females were injected with Adriamycin drug after oral administration with preventive dose of honey and royal jelly and another 25 females were injected with Adriamycin drug after oral administration with preventive dose of ginseng. histologically study of the ovaries and sex hormones.
Results: ginseng root herb is not considered a sufficient preventive supplement, as it did not protect the tissue structures. However, it contributes to raising the levels of sex hormones. but the honey with royal jelly has a clear role in renovating and They protect the tissue structure of the ovary, enhancing the hormonal balance, and prevents the hormonal disorders, and the occurrence of early menopause caused by adriamycin.
Conclusion: The Honey with royal jelly contributes, as a preventive dose, in preventing the side effects of adriamycin drug, and reducing the reproductive aging and early menopause.

Keywords:

Adriamycin; Ginseng root herb; Graafian follicles; Honey; Menopause; Panax ginseng; Royal jelly; Sex hormones;
Syrian hamster.

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